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Uniformity is crucial. Table of contents, user guides, icons, menus, graphics, FAQs, and the look and feel of dashboards should all be very similar. The finance manager should be able to easily drive the credit or treasury dashboard because it looks and behaves similarly to the finance dashboard. It is a common theme to have a HOME button to take the user to a table of contents. A table of contents also appears to the left of the information, and the section and page the user is viewing is highlighted in a different color (see Exhibit 13.5).

Hudson et al. Birk & Spencer Stancin et al. Powers et al. Fairburn et al. Rodin et al. Striegel-Moore et al. Peveler et al. Biggs et al. Dunning et al. Polonsky et al. Cantwell et al. Affenito et al. Rydall et al. Bryden et al. Herpertz et al. Herpertz et al. Jones et al.

To generate a therapeutically valuable tissue mass, it is crucial to maintain and expand hES cells in an undifferentiated state Human ES cells require two to three environmental factors to prevent spontaneous differentiation The rst of these requirements are the factors derived from embryonic broblast feeder cells Embryonic broblasts can be derived from murine [Shamblott et al, 1998; Thomson et al, 1998] or human [Richards et al, 2002] sources to sustain the undifferentiated phenotype Thus far, most analysis on the use of cocultures to prevent hES cell differentiation has been performed on murine embryonic broblasts (MEFs) Before use, MEFs are mitotically inactivated, through either irradiation or application of mitomycin C, to prevent overgrowth of the feeder cells in the cocultures The factors that the MEF cells add to the medium are unknown, but they are crucial for maintaining hES cells in an undifferentiated state [Itskovitz-Eldor et al.

(16.207)

consolidation and business reinvention The triumph of new open standards provides an open playing eld: easy to access new markets and easy to access alternative information sources Innovations focus on new areas of services Some of these make spectacular successes while others fail just as spectacularly There is a constantly ageing but really well-off and culturally differentiated population Of the four scenarios described two are developed in more detail In the moderately dynamic marketplace, changes occur frequently, but along roughly predictable and linear paths [8] Typical for that market are relatively stable industry structures such that market boundaries are clear and the players (eg competitors, customers) are well known The new services are added to the business in the context of the existing rules and routines In this environment products and services are extended to include new functionalities and the actors form a vertical structure to provision the services.

, 2000; Reubinoff et al, 2000; Thomson et al, 1998] There are two methods for using MEFs to prevent the differentiation of hES In the rst method, hES cells are cultured directly on a monolayer of mitotically inactivated MEFs [Itskovitz-Eldor et al, 2000; Thomson et al, 1998], allowing for free exchange of MEF-secreted factors with the ES cells In the second method, hES cells are grown on a layer of diluted Matrigel, which simulates the extracellular matrix that the MEFs provide [Xu et al, 2001] The ES medium that is fed to these cells is derived from medium conditioned by mitotically inactivated MEFs for approximately 24 hours Thus the unknown factors that MEFs provide are available to the hES cells without their direct contact [Xu et al, 2001] This second scenario is useful for applications when MEF contamination in subsequent steps is undesirable.

often successful because 27% of the patients completely denied their eating disorder, 46% minimized their problems and were reluctant to be treated and 19% dropped out after some weeks or months. Only 8% had a positive attitude towards treatment. Thus an important task for the general practitioner is to help the patients to recognize the seriousness of their disorder and to prepare and motivate them for specialist treatment (Silber & DeAngelo, 1991; Spaans & Bloks, 1997).

This scenario is described in the Old Rules scenario In a very dynamic marketplace the change becomes nonlinear and even less predictable Market boundaries are blurred, successful business models are unclear, and market actors are ambiguous and shifting [8] The overall industry structure is unclear In these markets development necessarily rely much less on existing knowledge and much more on rapidly created situation-speci c new knowledge Organisations rely on limited routines and they are looking for new ways to collaborate in modelling the business to meet the opportunities on the marketplace This scenario is described in the Wind Turns scenario Sections 9322 and 9323 discuss several environmental forces relevant for the two scenarios, focusing on the domains of economy, business, industry, society, users and technology.